Prednisolone: Contraindications. Depending on the indication and the general situation, peptic ulcers, osteoporosis, psychoses, infections, diabetes and. Contraindications for systemic glucocorticoids include systemic fungal Status asthmaticus is a contraindication for inhalative glucocorticoids. prednisone. Mechanism: It is a synthetic glucocorticoid with mineralocorticoid activities. It has a very rapid action. Naturally occurring glucocorticoids (hydrocortisone and.