Taking prednisolone can make you more likely to get infections. fever, chills, a very sore throat, ear or sinus pain, a cough, more saliva or a change in colour of. Reviews and ratings for prednisone when used in the treatment of sinusitis. 35 reviews submitted. (Reuters Health) - The steroid prednisolone is no better at reducing the symptoms of a sinus infection than a placebo, according to a new study. If you need any vaccinations, mention that you are taking a steroid. These side effects are rage prednisone likely to happen if you have taken prednisolone for more than a few weeks or you take more than 40mg daily. Couldn't breath through my nose and daily headaches, brain fog and congestion plagued my life. Rosenfeld said nasal spray decongestants and saline irrigation products, such as a neti pot, can help relieve symptoms. Prednisone is the only treatment which has provided much appreciated relief. High doses or long-term use can also affect the unborn baby's growth. The location of sinus pain depends on which sinus is affected. The downside is it sent my anxiety through the roof and I didn't sleep for a week but after a year of chronic sinus problems it was nothing!! Differentiating it from a common viral URTI is most important. Steroids are the most effective anti-inflammatory drugs available, and are derivatives of natural hormones which the body creates to help sinnus body cope with injury or stress. I was hesitant at first knowing others who have taken Pred. If you need any medical or dental treatment, show your blue prednisons card see more the doctor or dentist so they know that you are taking prednisolone.